Innovative Approaches to Vial Closure and Sealing Systems for Improved Sample Security and Data Reliability

Optimal Tightening Attempt, 9mm Closure Source D. Sample Evaporation (g) 0.020 0.015 0.010 0.005 0 0.025. Normal Tightening, SureStop Vial/AVCS Closure. Sample Evaporation (g) Sample Number 0.020 0.015 0.010 0.005 0.025. Crimp Seal Reference, Overcrimped. Sample Evaporation (g) 0.040 0.030 0.020 0.010 0 0.050 0.060. Overtightened 9mm Closure

From improved autosampler compatibility, to elimination of inconsistent vials sealing that threatens to destroy sample integrity, to increased flexibility and handling with vial/ septa combinations, the 9 mm closure will drive your laboratory to even greater performance levels. At the core of the new National series of closures is the Advanced

In this paper, we demonstrated a comprehensive approach utilizing real CCS component dimensional data as a statistical input for CCS dimension stack-up calculations to calculate the actual CCS end performance window and the CCS's quantitative failure risk to determine the CCS's optimal sealing performance and visual acceptance under different st

Autosampler Vials Thermo Scientific™ 9mm Clear Glass Screw Thread Vials Nearly eliminate septa push-through and improve sealing with vials built with the innovative Advanced Vial Closure System (AVCS).

This prevents the vial from being an optimal seal which eliminates under- and over-sealing by the cap/closure, and user-to-user variance. SureStop vials are designed for use with AVCS system screw caps. They improve transfer reliability and give a more secure liquid seal than standard screw vials.

container and closure systems’. The sample size is also not mandated but should be based on ‘informationand process knowledge’. If one equates ‘knowledge of the container, closure systems, and process’ to mean ‘data on the container, closure systems, and process’, one comes to the conclusion that scientific CCI studies

when sealing a vial. Analytical results are improved as a result of the elimination of evaporation differences between samples. PAGE 2-005 Virtuoso Vial Identification System A fast sample identity and security system that provides reliable and accurate customized sample information printed directly onto a vial. Thermo Scientific PAGE 2-007

2. Re-analysis costs are reduced, sample data integrity and sample throughput increases 3. No need to use bulky crimpers – AVCS closures with SureStop vials seal as well as crimp top vials 4. The leveling feature of AVCS designed vials gives more autosampler compatibility with less autosampler interruptions, due to mishandled vials 5.

A one-year study to establish the container closure integrity (CCI) performance landscape of systems comprising rubber stoppers and glass vials was performed. Focus was on addressing the issues of CCI performance versus: (a) time, (b) compression levels and residual seal force (RSF) values, and (c) .

Feb 14, 2020 · Compatible vial container closure system (CCS) components in combination with a proper capping process are crucial to ensuring reliable performance, maintaining container closure integrity (CCI), and CCS visual acceptance. CCI is essential for parenteral packaging and must be maintained throughout the entire sealed drug product life.

17. Thermo Scientific™ 9mm Clear Glass Screw Thread Vials. Nearly eliminate septa push-through and improve sealing with vials built with the innovative Advanced Vial Closure System (AVCS). 18. Fisherbrand™ 9mm Short Thread Vial Kit, PP, Clear, 1.5mL, PP Screw Cap, Center Hole, Silicone/PTFE Septum. Includes 100 vials and 100 caps with pre

Autosampler Vials, Caps and Closures Thermo Scientific™ 8mm Non-Assembled Clear Screw Thread Autosampler Vial Kits Save time and reduce the risk of contamination using this convenience kit.

Sep 3, 2021 · A typical vial container closure system configuration has three major components: a vial, an elastomer stopper, and an aluminum seal with or without a flip-off button. 5 Among these container closure system components, the elastomer stopper plays a critical role by deforming to seal the vial-stopper interface area either temporarily or permanently.

Feb 23, 2021 · Materials. Tubing vials with a 20 mL nominal fill volume by MGlas (Münnerstadt, Germany) were used in the LS experiments. 10 mL and 20 mL tubing vials by Ompi (Piombino Dese, Italy) were used in the PC experiments. 20 mm Westar ® RS stoppers (West Pharmaceutical Services, Exton, PA) were used in conjunction with the LS as recommended by the manufacturer and for the regularly stoppered vials

Crimp Seal Reference: Optimal Crimp. Sample Evaporation (g) 0.020 0.015 0.010 0.005 0 0.025. Optimal Tightening Attempt, 9mm Closure Source C. 0.040 0.030 0.020 0.010 0 0.050. Optimal Tightening Attempt, 9mm Closure Source D. Sample Evaporation (g) 0.020 0.015 0.010 0.005 0 0.025. Normal Tightening, SureStop Vial/AVCS Closure. Sample